PCBD2 and KCNIP3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PCBD2	KCNIP3
Description		pterin-4 alpha-carbinolamine dehydratase 2	potassium voltage-gated channel interacting protein 3
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GO Annotations	Cellular Component	Cellular_component Nucleus	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways			Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		33 interacting genes: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A F2RL1 FBXO7 GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	18 interacting genes: CALM2 CASP3 CD177 CLN3 CREB1 CREM CTBP2 GRK2 GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2
Entrez ID		84105	30818
HPRD ID		17824	05232
Ensembl ID		ENSG00000132570	ENSG00000115041
Uniprot IDs		Q9H0N5	A0A024RE22 Q9Y2W7
PDB IDs		4C45	2E6W
Enriched GO Terms of Interacting Partners?
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