CAST and PPFIA1

Number of citations of the paper that reports this interaction (PubMedID 12923177)
60

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CAST	PPFIA1
Description		calpastatin	PTPRF interacting protein alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane	Cytoplasm Cytosol Focal Adhesion Axon Dendrite Protein-containing Complex Presynaptic Active Zone
	Molecular Function	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding	Protein Binding
	Biological Process	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Cell-matrix Adhesion Signal Transduction Neurotransmitter Secretion Glutamate Secretion Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs		Calcium Artenimol
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 26426971) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Coronary artery disease ( 29212778)
Interacting Genes		10 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4	26 interacting genes: AGTPBP1 CAGE1 CAST CCNH CEP70 DNAJC5 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA YWHAG
Entrez ID		831	8500
HPRD ID		00233	11451
Ensembl ID		ENSG00000153113	ENSG00000131626
Uniprot IDs		B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9	B3KVS8 Q13136
PDB IDs			1N7F
Enriched GO Terms of Interacting Partners?
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