CAST and PPFIA4

Number of citations of the paper that reports this interaction (PubMedID 12923177)
60

Data Source:
HPRD (two hybrid, in vitro)

		CAST	PPFIA4
Description		calpastatin	PTPRF interacting protein alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane	Cytosol Cell Surface Synapse Presynaptic Active Zone
	Molecular Function	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding	Protein Binding
	Biological Process	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Neurotransmitter Secretion Glutamate Secretion Synapse Organization
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs		Calcium Artenimol
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 26426971) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 30061737 29892015) Early onset atrial fibrillation ( 28460022)
Interacting Genes		10 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4	6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2
Entrez ID		831	8497
HPRD ID		00233	16012
Ensembl ID		ENSG00000153113	ENSG00000143847
Uniprot IDs		B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9	B3KN22 B4DIS5 O75335
PDB IDs
Enriched GO Terms of Interacting Partners?
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