USP11 and CBX8

Number of citations of the paper that reports this interaction (PubMedID 20601937)
53

Data Source:
BioGRID (affinity chromatography technology, pull down)

		USP11	CBX8
Description		ubiquitin specific peptidase 11	chromobox 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide
Pathways		Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS			General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		18 interacting genes: BMI1 BRCA2 CBX8 CDKN1A EIF4B H2AX LLGL1 PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC	36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14
Entrez ID		8237	57332
HPRD ID		02081	13006
Ensembl ID		ENSG00000102226	ENSG00000141570
Uniprot IDs		B4DGK3 P51784	Q9HC52
PDB IDs		4MEL 5OK6	2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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