CBX8 and RING1

Number of citations of the paper that reports this interaction (PubMedID 10825164)
29

Data Source:
HPRD (in vivo, two hybrid)

		CBX8	RING1
Description		chromobox 8	ring finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)	Wegener's granulomatosis ( 23740775)
Interacting Genes		36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14	24 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 PHC1 PIK3R3 RB1 RNF2 RYBP TP53 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K
Entrez ID		57332	6015
HPRD ID		13006	03624
Ensembl ID		ENSG00000141570	ENSG00000204227
Uniprot IDs		Q9HC52	A0A1U9X8F2 Q06587
PDB IDs		2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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