CBX8 and TSGA10

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CBX8	TSGA10
Description		chromobox 8	testis specific 10
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Cellular_component Cytoplasm Centriole Sperm Fibrous Sheath Neuron Projection Sperm Principal Piece
	Molecular Function	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide	Spermatogenesis Cell Projection Assembly
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)	Bipolar disorder ( 21926972) Intelligence (MTAG) ( 29326435)
Interacting Genes		36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14	42 interacting genes: AXIN1 BCL6B BIRC2 CBX8 CBY2 CCDC33 CCHCR1 CDC73 CDK18 CEP44 CEP57L1 CREB5 FAM161A FBF1 GCC2-AS1 HIF1A KRT6A LMNA MID2 PPHLN1 PPP1R18 PRPF31 RCOR3 RNF6 RTP5 SCEL SYT6 TCEA2 TLE5 TRIM29 ZBTB24 ZBTB38 ZNF124 ZNF2 ZNF410 ZNF417 ZNF426 ZNF490 ZNF544 ZNF587 ZNF599 ZNF670
Entrez ID		57332	80705
HPRD ID		13006	06202
Ensembl ID		ENSG00000141570	ENSG00000135951
Uniprot IDs		Q9HC52	A0A218MIY9 Q9BZW7
PDB IDs		2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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