ELL and EAF2

Number of citations of the paper that reports this interaction (PubMedID 12446457)
35

Data Source:
HPRD (in vivo)

		ELL	EAF2
Description		elongation factor for RNA polymerase II	ELL associated factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Speck Transcriptionally Active Chromatin Histone Locus Body	Nucleoplasm Transcription Elongation Factor Complex Nuclear Speck ELL-EAF Complex
	Molecular Function	Protein Binding Phosphatase Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	In Utero Embryonic Development Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Phosphatase Activity Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Apoptotic Process Negative Regulation Of Cell Growth Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Breast cancer ( 29059683 23535729) Coronary artery disease ( 29212778) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Pulse pressure ( 30224653)
Interacting Genes		11 interacting genes: EAF1 EAF2 HNRNPU MCM2 POLR2A PRKACA SNF8 TFPT TP53 UBC ZHX1	20 interacting genes: BEND7 BIRC2 ELL GOLGA2 HIF1A IHO1 LNX2 NECAB2 PNMA1 PSME3 RBPMS SSX2IP STAC3 TCEA1 TCEA2 TFIP11 TFPT TLE5 TP53 TRIM23
Entrez ID		8178	55840
HPRD ID		02615	09634
Ensembl ID		ENSG00000105656	ENSG00000145088
Uniprot IDs		P55199 U3KQ90	B4DWJ3 Q96CJ1
PDB IDs		2DOA
Enriched GO Terms of Interacting Partners?
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