TSGA10 and CBX8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TSGA10	CBX8
Description		testis specific 10	chromobox 8
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Centriole Sperm Fibrous Sheath Neuron Projection Sperm Principal Piece	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Molecular_function Protein Binding	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Spermatogenesis Cell Projection Assembly	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Intelligence (MTAG) ( 29326435)	General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		42 interacting genes: AXIN1 BCL6B BIRC2 CBX8 CBY2 CCDC33 CCHCR1 CDC73 CDK18 CEP44 CEP57L1 CREB5 FAM161A FBF1 GCC2-AS1 HIF1A KRT6A LMNA MID2 PPHLN1 PPP1R18 PRPF31 RCOR3 RNF6 RTP5 SCEL SYT6 TCEA2 TLE5 TRIM29 ZBTB24 ZBTB38 ZNF124 ZNF2 ZNF410 ZNF417 ZNF426 ZNF490 ZNF544 ZNF587 ZNF599 ZNF670	36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14
Entrez ID		80705	57332
HPRD ID		06202	13006
Ensembl ID		ENSG00000135951	ENSG00000141570
Uniprot IDs		A0A218MIY9 Q9BZW7	Q9HC52
PDB IDs			2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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