ARHGEF5 and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ARHGEF5	FKBP8
Description		Rho guanine nucleotide exchange factor 5	FKBP prolyl isomerase 8
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Binding Involved In Protein Folding Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Ub-specific processing proteases
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Post bronchodilator FEV1/FVC ratio ( 26634245)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		16 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 CRKL EFHC2 FKBP8 HSPBAP1 NR4A1 PLCG1 SEPHS2 SLU7 TRIM27 TRIM54	17 interacting genes: ANKMY2 ARHGEF5 ATP13A2 BCL2 BCL2L1 BNIPL CLCN1 EGFR EGLN1 MAPK14 MTOR PPP3CA PSMC1 PSMD2 RHEB TERF1 VHL
Entrez ID		7984	23770
HPRD ID		02932	05327
Ensembl ID		ENSG00000050327	ENSG00000105701
Uniprot IDs		Q12774	A0A024R7P2 B2R8G6 Q14318
PDB IDs			2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?
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