ARHGEF5 and SEPHS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ARHGEF5	SEPHS2
Description		Rho guanine nucleotide exchange factor 5	selenophosphate synthetase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery	Cellular_component Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Selenide, Water Dikinase Activity ATP Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Selenium Compound Metabolic Process Selenocysteine Metabolic Process Selenocysteine Biosynthetic Process Phosphorylation
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Selenocysteine synthesis
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		16 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 CRKL EFHC2 FKBP8 HSPBAP1 NR4A1 PLCG1 SEPHS2 SLU7 TRIM27 TRIM54	1 interacting genes: ARHGEF5
Entrez ID		7984	22928
HPRD ID		02932	12096
Ensembl ID		ENSG00000050327	ENSG00000179918
Uniprot IDs		Q12774	Q99611
PDB IDs
Enriched GO Terms of Interacting Partners?
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