SEPHS2 and ARHGEF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SEPHS2	ARHGEF5
Description		selenophosphate synthetase 2	Rho guanine nucleotide exchange factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	Selenide, Water Dikinase Activity ATP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Selenium Compound Metabolic Process Selenocysteine Metabolic Process Selenocysteine Biosynthetic Process Phosphorylation	Myeloid Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import
Pathways		Selenocysteine synthesis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		1 interacting genes: ARHGEF5	16 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 CRKL EFHC2 FKBP8 HSPBAP1 NR4A1 PLCG1 SEPHS2 SLU7 TRIM27 TRIM54
Entrez ID		22928	7984
HPRD ID		12096	02932
Ensembl ID		ENSG00000179918	ENSG00000050327
Uniprot IDs		Q99611	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?
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