UBE2A and HLTF

Number of citations of the paper that reports this interaction (PubMedID 22904075)
19

Data Source:
BioGRID (enzymatic study)

		UBE2A	HLTF
Description		ubiquitin conjugating enzyme E2 A	helicase like transcription factor
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GO Annotations	Cellular Component	Chromatin Nuclear Chromatin XY Body Nucleoplasm Cytosol HULC Complex	Nucleus Nucleoplasm Nucleolus Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Blastocyst Hatching DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Proliferation Response To UV Protein Ubiquitination Histone Ubiquitination Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)
Interacting Genes		26 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 HLTF KCMF1 MDM2 PCNA PRKN RAD18 RC3H1 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	14 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4
Entrez ID		7319	6596
HPRD ID		02422	04461
Ensembl ID		ENSG00000077721	ENSG00000071794
Uniprot IDs		A0A0D9SG71 P49459	A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527
PDB IDs		6CYO 6CYR	2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F
Enriched GO Terms of Interacting Partners?
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