HLTF and UBE2V2

Number of citations of the paper that reports this interaction (PubMedID 18316726)
85

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, pull down)

		HLTF	UBE2V2
Description		helicase like transcription factor	ubiquitin conjugating enzyme E2 V2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm UBC13-MMS2 Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Height ( 31562340)
Interacting Genes		14 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4	33 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LNX1 LRIF1 MALT1 MKRN3 MOB4 MUL1 OTUB1 RC3H1 RC3H2 RFFL RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM21 TRIM5 TRIM54 TRIM63 UBC UBE2N XIAP ZNRF1
Entrez ID		6596	7336
HPRD ID		04461	04300
Ensembl ID		ENSG00000071794	ENSG00000169139
Uniprot IDs		A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527	A0M8W4 Q15819
PDB IDs		2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F	1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT
Enriched GO Terms of Interacting Partners?
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