RDX and ABCC2

Number of citations of the paper that reports this interaction (PubMedID 12068294)
63

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RDX	ABCC2
Description		radixin	ATP binding cassette subfamily C member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Space Plasma Membrane Microvillus Focal Adhesion Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Stereocilium Cell Tip Extracellular Exosome Cell Periphery	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus
	Molecular Function	RNA Binding Actin Binding Protein Binding Protein Domain Specific Binding Cadherin Binding Protein Kinase A Binding ATPase Binding	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity
	Biological Process	Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Microvillus Assembly Positive Regulation Of Cell Migration Regulation Of Actin Filament Bundle Assembly Regulation Of Rap Protein Signal Transduction Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of GTPase Activity Apical Protein Localization Establishment Of Protein Localization Negative Regulation Of Cell Size Barbed-end Actin Filament Capping Establishment Of Endothelial Barrier Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Xenobiotic Catabolic Process Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Benzylpenicillin Metabolic Process Drug Transmembrane Export Drug Transport Across Blood-brain Barrier
Pathways		Recycling pathway of L1 Recycling pathway of L1	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome
Drugs		1D-myo-inositol 1,4,5-trisphosphate	ATP Sulfinpyrazone
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Cognitive function ( 24684796) Multiple sclerosis ( 31604244)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748)
Interacting Genes		19 interacting genes: ABCC2 ARHGDIA CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR GNA13 ICAM2 ITGB2 KMT2A L1CAM ROCK1 SLC9A3R1 SLC9A3R2 TSC1 VPS11 VWA5A	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1
Entrez ID		5962	1244
HPRD ID		01534	03065
Ensembl ID		ENSG00000137710	ENSG00000023839
Uniprot IDs		B0YJ88 P35241 Q6PKD3	Q92887
PDB IDs
Enriched GO Terms of Interacting Partners?
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