ABCC2 and AZIN1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCC2	AZIN1
Description		ATP binding cassette subfamily C member 2	antizyme inhibitor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity	Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity
	Biological Process	Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Xenobiotic Catabolic Process Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Benzylpenicillin Metabolic Process Drug Transmembrane Export Drug Transport Across Blood-brain Barrier	Regulation Of Cellular Amino Acid Metabolic Process Putrescine Biosynthetic Process From Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Polyamine Transmembrane Transport
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome	Regulation of ornithine decarboxylase (ODC)
Drugs		ATP Sulfinpyrazone
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748)	Airway imaging phenotypes ( 26030696) Granulocyte count ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252) QT interval ( 24952745) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1	6 interacting genes: ABCC2 ADSS1 CDKN2A FANCA FANCC KHDRBS1
Entrez ID		1244	51582
HPRD ID		03065	07443
Ensembl ID		ENSG00000023839	ENSG00000155096
Uniprot IDs		Q92887	A0A024R9C7 B3KTF6 O14977
PDB IDs			4ZGZ
Enriched GO Terms of Interacting Partners?
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