ABCC2 and SHANK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCC2	SHANK3
Description		ATP binding cassette subfamily C member 2	SH3 and multiple ankyrin repeat domains 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus	Cell Cytosol Ionotropic Glutamate Receptor Complex Postsynaptic Density Cell Junction Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding Protein Self-association Scaffold Protein Binding
	Biological Process	Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Xenobiotic Catabolic Process Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Benzylpenicillin Metabolic Process Drug Transmembrane Export Drug Transport Across Blood-brain Barrier	MAPK Cascade Axon Guidance Synapse Assembly Behavior Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome
Drugs		ATP Sulfinpyrazone
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748)	Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Intelligence (MTAG) ( 29326435) Memory dysfunction in frontotemporal lobe dementia ( 29724592)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1	17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8
Entrez ID		1244	85358
HPRD ID		03065	18979
Ensembl ID		ENSG00000023839	ENSG00000251322
Uniprot IDs		Q92887
PDB IDs
Enriched GO Terms of Interacting Partners?
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