RAB5C and EEA1

Number of citations of the paper that reports this interaction (PubMedID 12493736)
17

Data Source:
HPRD (in vitro)

		RAB5C	EEA1
Description		RAB5C, member RAS oncogene family	early endosome antigen 1
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Lipid Droplet Plasma Membrane Endomembrane System Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Nucleic Acid Binding Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Rab Protein Signal Transduction Neutrophil Degranulation Plasma Membrane To Endosome Transport	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Toll Like Receptor 9 (TLR9) Cascade
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)
Interacting Genes		19 interacting genes: APP APPL2 CCR10 DGKI EEA1 GLP1R HOXB13 HRAS INCA1 KRT15 RABAC1 RAPGEFL1 RBSN RIN2 RIN3 SGSM3 SLC27A2 TBC1D15 TBC1D17	13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		5878	8411
HPRD ID		04947	05460
Ensembl ID		ENSG00000108774	ENSG00000102189
Uniprot IDs		A0A024R1U4 P51148	Q15075
PDB IDs		4KYI	1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?
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