ANKRA2 and F2RL1

		ANKRA2	F2RL1
Description		ankyrin repeat family A member 2	F2R like trypsin receptor 1
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex	Cell Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Complex Assembly	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Chemokine (C-C Motif) Ligand 2 Secretion Neutrophil Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Interleukin-1 Beta Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Interleukin-10 Secretion Interferon-gamma Secretion Chemokine Secretion Negative Regulation Of Chemokine Secretion Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Monobrow thickness ( 26926045)	Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)
Interacting Genes		12 interacting genes: ABL1 APP CDKN2A F2RL1 HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7	21 interacting genes: ANKRA2 CAPN1 CAPN2 CBL COPS5 CTSG CYFIP2 DNMT3L ELANE F2 F2R GPRASP1 JMY LMNA MAP1B NUMA1 PCBD2 PLG PRTN3 RAD17 ST14
Entrez ID		57763	2150
HPRD ID		12044	02960
Ensembl ID		ENSG00000164331	ENSG00000164251
Uniprot IDs		A0A024RAN7 Q9H9E1	P55085
PDB IDs		3SO8 3V2O 3V2X 3V31 4LG6 4QQI	5NDD 5NDZ 5NJ6
Enriched GO Terms of Interacting Partners?
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