F2RL1 and PRTN3

Number of citations of the paper that reports this interaction (PubMedID 10978167)
21

Data Source:
HPRD (in vitro, in vivo)

		F2RL1	PRTN3
Description		F2R like trypsin receptor 1	proteinase 3
Image
GO Annotations	Cellular Component	Cell Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium	Extracellular Region Extracellular Space Cytosol Plasma Membrane Azurophil Granule Lumen Plasma Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding
	Biological Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Chemokine (C-C Motif) Ligand 2 Secretion Neutrophil Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Interleukin-1 Beta Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Interleukin-10 Secretion Interferon-gamma Secretion Chemokine Secretion Negative Regulation Of Chemokine Secretion Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion	Proteolysis Membrane Protein Ectodomain Proteolysis Phagocytosis Blood Coagulation Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs			Elafin
Diseases
GWAS		Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Blood protein levels ( 30072576 29875488) Monocyte percentage of white cells ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		21 interacting genes: ANKRA2 CAPN1 CAPN2 CBL COPS5 CTSG CYFIP2 DNMT3L ELANE F2 F2R GPRASP1 JMY LMNA MAP1B NUMA1 PCBD2 PLG PRTN3 RAD17 ST14	13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		2150	5657
HPRD ID		02960	01512
Ensembl ID		ENSG00000164251	ENSG00000196415
Uniprot IDs		P55085	P24158
PDB IDs		5NDD 5NDZ 5NJ6	1FUJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?