EXOSC5 and LIPG

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		EXOSC5	LIPG
Description		exosome component 5	lipase G, endothelial type
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Lipoprotein Lipase Activity Phospholipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Lipid Metabolic Process Response To Nutrient Cell Proliferation Phospholipid Catabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Lipid Catabolic Process Positive Regulation Of Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Regulation Of Lipoprotein Metabolic Process Phospholipid Homeostasis
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	HDL remodeling
Drugs
Diseases
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Apolipoprotein A1 levels ( 29084231) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol ester levels in very large HDL ( 29084231) Cholesterol, total ( 24097068 19060911 25961943 20686565) Coronary artery disease ( 29212778) Free cholesterol levels in medium HDL ( 29084231) HDL cholesterol ( 24097068 20031538 31170924 28270201 24507774 18193043 18193044 20864672 19060906 19060911 30275531 25961943 20686565 26582766) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010 31217584) Large HDL particle concentration ( 29084231) LDL cholesterol ( 30275531) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 23666239) Total cholesterol levels ( 28334899 29403010 30275531) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		45 interacting genes: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DMRTB1 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FHL3 GOLGA2 HAMP HBS1L IKZF3 KIAA1217 KMT2A KRT13 LIPG LSM3 LSM5 MPHOSPH6 MPP6 MTREX NMI NUP210 PA2G4 PAF1 PKM POLR2L PRODH2 REL SFPQ SH3GLB1 SH3GLB2 TEX11 TNFAIP1 TRIM54 ZNF558	2 interacting genes: EXOSC5 FANCA
Entrez ID		56915	9388
HPRD ID		16222	04730
Ensembl ID		ENSG00000077348	ENSG00000101670
Uniprot IDs		Q9NQT4	A0A024R2B5 B4DTR8 Q9Y5X9
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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