EXOSC5 and MPHOSPH6

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EXOSC5	MPHOSPH6
Description		exosome component 5	M-phase phosphoprotein 6
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	RNA Binding Protein Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Maturation Of 5.8S RRNA RRNA Processing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Leukocyte telomere length ( 31171785) Lung adenocarcinoma ( 28604730) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)
Interacting Genes		45 interacting genes: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DMRTB1 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FHL3 GOLGA2 HAMP HBS1L IKZF3 KIAA1217 KMT2A KRT13 LIPG LSM3 LSM5 MPHOSPH6 MPP6 MTREX NMI NUP210 PA2G4 PAF1 PKM POLR2L PRODH2 REL SFPQ SH3GLB1 SH3GLB2 TEX11 TNFAIP1 TRIM54 ZNF558	33 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSBP1 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		56915	10200
HPRD ID		16222	16111
Ensembl ID		ENSG00000077348	ENSG00000135698
Uniprot IDs		Q9NQT4	H3BNT4 Q99547
PDB IDs		2NN6 6D6Q 6D6R 6H25	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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