EXOSC5 and PRODH2

		EXOSC5	PRODH2
Description		exosome component 5	proline dehydrogenase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Proline Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-NH Group Of Donors FAD Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Proline Catabolic Process Proline Catabolic Process To Glutamate Glyoxylate Metabolic Process Oxidation-reduction Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Glyoxylate metabolism and glycine degradation Proline catabolism
Drugs
Diseases
GWAS
Interacting Genes		45 interacting genes: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DMRTB1 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FHL3 GOLGA2 HAMP HBS1L IKZF3 KIAA1217 KMT2A KRT13 LIPG LSM3 LSM5 MPHOSPH6 MPP6 MTREX NMI NUP210 PA2G4 PAF1 PKM POLR2L PRODH2 REL SFPQ SH3GLB1 SH3GLB2 TEX11 TNFAIP1 TRIM54 ZNF558	1 interacting genes: EXOSC5
Entrez ID		56915	58510
HPRD ID		16222	17911
Ensembl ID		ENSG00000077348	ENSG00000250799
Uniprot IDs		Q9NQT4	A0A590UKC3 Q9UF12
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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