BTBD2 and TRIM5

Number of citations of the paper that reports this interaction (PubMedID 12878161)
45

Data Source:
HPRD (in vitro)

		BTBD2	TRIM5
Description		BTB domain containing 2	tripartite motif containing 5
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GO Annotations	Cellular Component	P-body Cytosol	P-body Nucleus Cytoplasm Cytosol Omegasome
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Binding, Bridging Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Neurogenesis	Activation Of Innate Immune Response Autophagy Viral Process Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Mitochondrial DNA copy number (white blood cells) ( 30704525) Platelet count ( 27863252)	Coronary artery disease ( 29212778) DNA methylation (variation) ( 23725790) Mean platelet volume ( 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		28 interacting genes: BRD7 CCDC90B CDK2 COPS6 CRMP1 DPPA4 EEF1A1 ERG28 GAPDH GBP2 GDF9 IGSF21 KPNA2 PTN RBM48 SETDB1 SMAD1 SMAD2 TDP2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B ZYG11B	38 interacting genes: BTBD1 BTBD2 EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5
Entrez ID		55643	85363
HPRD ID		12252	07004
Ensembl ID		ENSG00000133243	ENSG00000132256
Uniprot IDs		Q9BX70	Q9C035
PDB IDs		3NO8	2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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