TRIM5 and TRIM35

Number of citations of the paper that reports this interaction (PubMedID 16775307)
35

Data Source:
BioGRID (pull down)

		TRIM5	TRIM35
Description		tripartite motif containing 5	tripartite motif containing 35
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Binding, Bridging Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity	Molecular_function Zinc Ion Binding
	Biological Process	Activation Of Innate Immune Response Autophagy Viral Process Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell	Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways		Interferon gamma signaling	Interferon gamma signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) DNA methylation (variation) ( 23725790) Mean platelet volume ( 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010) Serum alkaline phosphatase levels ( 29403010)	Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)
Interacting Genes		38 interacting genes: BTBD1 BTBD2 EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5	14 interacting genes: PAN2 PKM TRIM11 TRIM5 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49
Entrez ID		85363	23087
HPRD ID		07004	15553
Ensembl ID		ENSG00000132256	ENSG00000104228
Uniprot IDs		Q9C035	E5RGB3 Q9UPQ4
PDB IDs		2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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