PRKAA2 and RPTOR

  • Number of citations of the paper that reports this interaction (PubMedID 18439900)
  • 1185
  • Data Source:
  • BioGRID (enzymatic study)

PRKAA2

RPTOR

Description protein kinase AMP-activated catalytic subunit alpha 2 regulatory associated protein of MTOR complex 1
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Bipolar disorder ( 31043756)
  • Body mass index ( 28892062 25673413)
  • Hypertension ( 30487518)
  • Mean arterial pressure ( 30487518)
  • NASH resolution in nonalcoholic steatohepatitis ( 31832568)
  • Obesity ( 23563607)
  • Pulse pressure ( 29403010 30487518)
  • Systolic blood pressure ( 30487518)
Interacting Genes 52 interacting genes: ABI2 ACACA ACACB AIMP2 APPBP2 C19orf47 CCNB1IP1 DNMT1 EEF2K EPM2A FOS GLI1 HAT1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NLA NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAG1 RBBP7 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TFAP2A TLE5 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 USP10 VPS52 WWP1 ZBTB8A ZNF397 22 interacting genes: CILK1 DUXAP9 EIF4EBP1 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB WIPI2
Entrez ID 5563 57521
HPRD ID 02735 06184
Ensembl ID ENSG00000162409 ENSG00000141564
Uniprot IDs P54646 Q6DKI0 Q8N122
PDB IDs 2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6 5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
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