PRKAA2 and RBPMS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PRKAA2	RBPMS
Description		protein kinase AMP-activated catalytic subunit alpha 2	RNA binding protein, mRNA processing factor
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Neuronal Cell Body	P-body Nucleoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Poly(A) Binding Protein Homodimerization Activity
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Lipid Biosynthetic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Drug Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Energy Homeostasis Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Peptidyl-lysine Acetylation	RNA Processing Response To Oxidative Stress Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Acetylsalicylic acid
Diseases
GWAS		Lymphocyte counts ( 22286170)	Blood urea nitrogen levels ( 31152163) Breast size ( 27182965) Granulocyte count ( 27863252) Heart rate variability traits ( 22174390) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular volume ( 29403010 27863252 28017375) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Platelet count ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Total grey matter volume ( 31530798)
Interacting Genes		52 interacting genes: ABI2 ACACA ACACB AIMP2 APPBP2 C19orf47 CCNB1IP1 DNMT1 EEF2K EPM2A FOS GLI1 HAT1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NLA NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAG1 RBBP7 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TFAP2A TLE5 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 USP10 VPS52 WWP1 ZBTB8A ZNF397	210 interacting genes: ABCF3 ADAM15 AMMECR1 ANKMY1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0D1 ATP6V0E2 ATXN1 BANP BBS2 BCL6B BHLHE40 BOLL C11orf87 C1orf94 C22orf39 C9orf24 CAMK2B CCER1 CCNG1 CCNK CDC23 CDC42EP1 CDK6 CHCHD7 CNNM3 CRBN CREB5 CRX CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DMRT3 DMRTB1 DOK3 DOK6 DPYSL4 DTX2 DVL2 EAF2 EFEMP2 ENKD1 EWSR1 EXOSC1 EYA2 FAM124B FAM168A FASTK FBF1 FBXL18 FNDC11 FOXC2 FOXP3 FOXS1 FRG1 FXR2 GATA1 GATAD2B GCM2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 GTF2F2 HEY2 HEYL HNRNPLL HOXA1 HOXA9 HOXB9 HOXC8 HSFY1 IGF2 ILF3 INCA1 INIP IP6K2 KCTD9 KIF1A KIR2DL4 KPNA2 KRAS KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP8-1 LASP1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LINC01869 LMO4 LONRF1 LRRC41 LZTS2 MAGED1 MCM5 MCM7 MEIS2 MGAT5B MKRN3 MORN3 MRPL20-AS1 MVP MYOZ2 NAB2 NANOG NAPRT NEDD9 NEU4 NR1D2 NTAQ1 NYNRIN OTX1 PATZ1 PDLIM4 PER1 PGLS PHF1 PICALM PIH1D1 PIN1 PITX1 PLAC8 POGZ POLR3GL POM121 PPP1R16B PRKAA1 PRKAA2 PRKAB2 PRR20A PSMF1 QKI R3HDM2 RABL6 RAD54L2 RAMAC RBFOX1 RBFOX2 RBM46 RDH12 RHOBTB3 RHOXF2 RIPPLY1 ROR2 RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SFI1 SH3RF2 SIRPB1 SMAD3 SMUG1 SNHG29 SNRPB SNRPC SPATA46 SPATA8 SPG7 STRBP TBX6 TCF7L2 TENT2 TEX37 TFG TIE1 TINAGL1 TLE5 TMSB4X TNS2 TOLLIP TOR1AIP2 TRAF4 TRIP13 TSG101 TTLL10 TUSC2 UBXN8 VENTX VHL VHLL VPS37C WDR54 WDR90 YPEL3 ZBTB32 ZC3H10 ZNF385C ZNF488 ZNF581
Entrez ID		5563	11030
HPRD ID		02735	11870
Ensembl ID		ENSG00000162409	ENSG00000157110
Uniprot IDs		P54646	B4E3T4 D3DSV0 Q93062
PDB IDs		2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6	1BNY 5CYJ 5DET
Enriched GO Terms of Interacting Partners?
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