AVPR2 and AVP

Number of citations of the paper that reports this interaction (PubMedID 11857925)
0

Data Source:
HPRD (in vivo)

		AVPR2	AVP
Description		arginine vasopressin receptor 2	arginine vasopressin
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cell Cytosol Secretory Granule Dendrite Clathrin-coated Vesicle Membrane
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Peptide Binding	Protein Kinase Activity Signaling Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Telencephalon Development Positive Regulation Of Protein Ubiquitination Interferon-gamma Production Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction Membrane Organization	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Water Transport Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Membrane Organization ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production	BMAL1:CLOCK,NPAS2 activates circadian gene expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Transport of organic anions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production
Drugs		Desmopressin Vasopressin Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan
Diseases		Congenital nephrogenic diabetes insipidus (NDI)	Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS
Interacting Genes		7 interacting genes: ARRB2 AVP C1QTNF1 GNAS GNB1 GNG2 GRK5	8 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR TXNDC17
Entrez ID		554	551
HPRD ID		02368	01891
Ensembl ID		ENSG00000126895	ENSG00000101200
Uniprot IDs		P30518	P01185 X5DQP6
PDB IDs		4JQI 6NI2
Enriched GO Terms of Interacting Partners?
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