AVPR2 and C1QTNF1

Number of citations of the paper that reports this interaction (PubMedID 12409230)
3

Data Source:
HPRD (in vitro, two hybrid)

		AVPR2	C1QTNF1
Description		arginine vasopressin receptor 2	C1q and TNF related 1
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Perinuclear Region Of Cytoplasm	Collagen Trimer Extracellular Space Cell Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Binding Peptide Binding	Protein Binding Collagen Binding Identical Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Telencephalon Development Positive Regulation Of Protein Ubiquitination Interferon-gamma Production Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction Membrane Organization	Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Platelet Aggregation Positive Regulation Of Aldosterone Secretion
Pathways		Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production
Drugs		Desmopressin Vasopressin Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS
Interacting Genes		7 interacting genes: ARRB2 AVP C1QTNF1 GNAS GNB1 GNG2 GRK5	7 interacting genes: AVPR2 CACNA1A LMNA LNX1 PRPF31 SGTA UBQLN4
Entrez ID		554	114897
HPRD ID		02368	12714
Ensembl ID		ENSG00000126895	ENSG00000173918
Uniprot IDs		P30518	A0A0C4DFP7 A0A3B0J271 Q9BXJ1
PDB IDs		4JQI 6NI2
Enriched GO Terms of Interacting Partners?
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