DCUN1D1 and CUL5

Number of citations of the paper that reports this interaction (PubMedID 30587576)
2

Data Source:
BioGRID (enzymatic study)

		DCUN1D1	CUL5
Description		defective in cullin neddylation 1 domain containing 1	cullin 5
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		25 interacting genes: ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CUL5 DAZAP2 DVL2 LAPTM5 LZTS2 MAP3K1 NEDD4 RHOA RNF11 SMAD2 TLE5 TP53BP2 TRIM39 TRIM54 UBC UBE2D3 UBE2F UBE2M VPS37B	34 interacting genes: ANAPC11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		54165	8065
HPRD ID		12067	03444
Ensembl ID		ENSG00000043093	ENSG00000166266
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q93034
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W	3DPL 3DQV 4JGH 4N9F
Enriched GO Terms of Interacting Partners?
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