CUL5 and DDX10

		CUL5	DDX10
Description		cullin 5	DEAD-box helicase 10
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GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	RNA Binding RNA Helicase Activity ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	RRNA Processing Anterior Head Development
Pathways		Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)
Interacting Genes		34 interacting genes: ANAPC11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL	16 interacting genes: ANTXR2 APP ARHGAP20 ARL2BP BCO2 CUL5 DES DSC3 FBXO7 HSPB2 IGFBP6 NPAT PGR PTS SIRPA SLN
Entrez ID		8065	1662
HPRD ID		03444	03138
Ensembl ID		ENSG00000166266	ENSG00000178105
Uniprot IDs		Q93034	Q13206
PDB IDs		3DPL 3DQV 4JGH 4N9F	2PL3
Enriched GO Terms of Interacting Partners?
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