ANAPC11 and MLKL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ANAPC11	MLKL
Description		anaphase promoting complex subunit 11	mixed lineage kinase domain like pseudokinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Protein Homotrimerization Necroptotic Process
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation	TRP channels RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Interacting Genes		26 interacting genes: ANAPC10 ANAPC2 ANAPC4 CAPN11 CCNB1 CDC16 CDC20 CUL5 FBXO5 FZR1 MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U ZAP70	5 interacting genes: ANAPC11 CDK1 NDUFB7 RAD18 THOC3
Entrez ID		51529	197259
HPRD ID		12452	08752
Ensembl ID		ENSG00000141552	ENSG00000168404
Uniprot IDs		A0A024R8S1 A0A087X1B5 Q9NYG5	Q8NB16
PDB IDs		2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H	2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74
Enriched GO Terms of Interacting Partners?
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