ANAPC11 and MAK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ANAPC11	MAK
Description		anaphase promoting complex subunit 11	male germ cell associated kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Centrosome Cilium Axoneme Midbody Motile Cilium Photoreceptor Connecting Cilium Mitotic Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Protein Phosphorylation Multicellular Organism Development Spermatogenesis Regulation Of Gene Expression Cell Differentiation Intracellular Signal Transduction Intraciliary Transport Photoreceptor Cell Maintenance Protein Autophosphorylation Cilium Assembly Negative Regulation Of Non-motile Cilium Assembly Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Menopause (age at onset) ( 26414677) Recurrent major depressive disorder ( 29317602) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		26 interacting genes: ANAPC10 ANAPC2 ANAPC4 CAPN11 CCNB1 CDC16 CDC20 CUL5 FBXO5 FZR1 MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U ZAP70	9 interacting genes: ANAPC11 APP FBXO7 FZR1 NDUFB7 PPP2CB SERINC1 SLAMF7 SND1
Entrez ID		51529	4117
HPRD ID		12452	01101
Ensembl ID		ENSG00000141552	ENSG00000111837
Uniprot IDs		A0A024R8S1 A0A087X1B5 Q9NYG5	A0A140VK28 F8VBW7 P20794
PDB IDs		2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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