MLKL and RAD18

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MLKL	RAD18
Description		mixed lineage kinase domain like pseudokinase	RAD18 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Protein Homotrimerization Necroptotic Process	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Protein Ubiquitination DNA Damage Response, Detection Of DNA Damage Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death
Pathways		TRP channels RIPK1-mediated regulated necrosis	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798)
Interacting Genes		5 interacting genes: ANAPC11 CDK1 NDUFB7 RAD18 THOC3	25 interacting genes: DZIP3 MAGEA4 MAP3K1 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7
Entrez ID		197259	56852
HPRD ID		08752	09242
Ensembl ID		ENSG00000168404	ENSG00000070950
Uniprot IDs		Q8NB16	Q9NS91
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74	2MRE 2MRF 2Y43 2YBF 5VF0
Enriched GO Terms of Interacting Partners?
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