PDE6G and GNAO1

Number of citations of the paper that reports this interaction (PubMedID 15215290)
25

Data Source:
HPRD (two hybrid)

		PDE6G	GNAO1
Description		phosphodiesterase 6G	G protein subunit alpha o1
Image
GO Annotations	Cellular Component	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Activation Of MAPK Activity Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway	PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Sildenafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases		Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825)	Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)
Interacting Genes		11 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 SLC27A2 SRC TRIP10	34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		5148	2775
HPRD ID		08914	00757
Ensembl ID		ENSG00000185527	ENSG00000087258
Uniprot IDs		P18545	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs		3JWR	6FUF 6G79 6OIK
Enriched GO Terms of Interacting Partners?
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