PDE6D and PTGIR

Number of citations of the paper that reports this interaction (PubMedID 16527812)
9

Data Source:
HPRD (in vivo)

		PDE6D	PTGIR
Description		phosphodiesterase 6D	prostaglandin I2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity
	Biological Process	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		ARL13B-mediated ciliary trafficking of INPP5E	Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	Crohn's disease ( 28067908)
Interacting Genes		24 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R
Entrez ID		5147	5739
HPRD ID		04056	08959
Ensembl ID		ENSG00000156973	ENSG00000160013
Uniprot IDs		B8ZZK5 O43924 Q6IB24	P43119
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
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