PDE6D and ARL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid, x-ray crystallography)
HPRD (in vitro)

		PDE6D	ARL2
Description		phosphodiesterase 6D	ADP ribosylation factor like GTPase 2
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Intermembrane Space Mitochondrial Matrix Golgi Apparatus Centrosome Cytosol Focal Adhesion Cilium Microtubule Cytoskeleton Lateral Plasma Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus	Tubulin Complex Assembly Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Regulation Of Insulin Secretion Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly
Pathways		ARL13B-mediated ciliary trafficking of INPP5E	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		24 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	6 interacting genes: ARL2BP PDE6D POLA2 TBCD TBL1XR1 UNC119
Entrez ID		5147	402
HPRD ID		04056	11869
Ensembl ID		ENSG00000156973	ENSG00000213465
Uniprot IDs		B8ZZK5 O43924 Q6IB24	P36404 Q53YD8
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW	3DOE 3DOF
Enriched GO Terms of Interacting Partners?
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