PDE6D and RAB18

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDE6D	RAB18
Description		phosphodiesterase 6D	RAB18, member RAS oncogene family
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Intracellular Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Secretory Granule Membrane Synapse Endoplasmic Reticulum Tubular Network
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Rab Protein Signal Transduction Lipid Droplet Organization Neutrophil Degranulation Import Into Nucleus Endoplasmic Reticulum Tubular Network Organization
Pathways		ARL13B-mediated ciliary trafficking of INPP5E	Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Warburg micro syndrome
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		24 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	13 interacting genes: APBB1IP CHM DVL3 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B PRTFDC1 TAX1BP1 TOM1L1 TREH UCN
Entrez ID		5147	22931
HPRD ID		04056	03731
Ensembl ID		ENSG00000156973	ENSG00000099246
Uniprot IDs		B8ZZK5 O43924 Q6IB24	A0A087X163 B7Z4P9 B7Z5V3 Q9NP72
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW	1X3S
Enriched GO Terms of Interacting Partners?
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