APIP and VPS25

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		APIP	VPS25
Description		APAF1 interacting protein	vacuolar protein sorting 25 homolog
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GO Annotations	Cellular Component	Cytoplasm Cytosol	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity	Structural Molecule Activity Protein Binding Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	Apoptotic Process L-methionine Salvage From S-adenosylmethionine L-methionine Salvage From Methylthioadenosine Negative Regulation Of Apoptotic Process Protein Homotetramerization Pyroptosis Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Endosomal Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Pathways		Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010) Lung disease severity in cystic fibrosis ( 26417704) Prostate-specific antigen levels ( 28139693) Systemic lupus erythematosus ( 19838195)
Interacting Genes		17 interacting genes: APAF1 CFAP206 IMPDH2 LNX1 NIF3L1 NTAQ1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 ZBTB25	11 interacting genes: APIP BEND5 CHMP6 CRLF3 DCAKD REL RHOXF2 SNF8 SPRY2 TRIM27 VPS36
Entrez ID		51074	84313
HPRD ID		14725	14396
Ensembl ID		ENSG00000149089	ENSG00000131475
Uniprot IDs		Q96GX9	A0A024R1X3 Q9BRG1
PDB IDs		4M6R	2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?
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