APIP and TNPO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		APIP	TNPO2
Description		APAF1 interacting protein	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity	Protein Binding Nuclear Localization Sequence Binding Ran GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Apoptotic Process L-methionine Salvage From S-adenosylmethionine L-methionine Salvage From Methylthioadenosine Negative Regulation Of Apoptotic Process Protein Homotetramerization Pyroptosis Regulation Of ERK1 And ERK2 Cascade	Protein Import Into Nucleus
Pathways		Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010) Lung disease severity in cystic fibrosis ( 26417704) Prostate-specific antigen levels ( 28139693) Systemic lupus erythematosus ( 19838195)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		17 interacting genes: APAF1 CFAP206 IMPDH2 LNX1 NIF3L1 NTAQ1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 ZBTB25	18 interacting genes: A1CF APIP C1orf94 CAMK2D CRYAB ELAVL1 EXOC5 KLHL2 NME1 NUP98 NXF1 PIK3CD PNMA5 RAN RPL4 TCL1B TERF1 TRMT1
Entrez ID		51074	30000
HPRD ID		14725	04301
Ensembl ID		ENSG00000149089	ENSG00000105576
Uniprot IDs		Q96GX9	A0A024R7F7 O14787 Q05D48 Q4LE60
PDB IDs		4M6R
Enriched GO Terms of Interacting Partners?
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