NFE2L1 and BACH2

Number of citations of the paper that reports this interaction (PubMedID 23661758)
49

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NFE2L1	BACH2
Description		nuclear factor, erythroid 2 like 1	BTB domain and CNC homolog 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Protein-containing Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Cholesterol Binding Protein Domain Specific Binding Protein-containing Complex Binding Promoter-specific Chromatin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Glutathione Metabolic Process Heme Biosynthetic Process Inflammatory Response Regulation Of Mitotic Nuclear Division Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells
Pathways
Drugs		Lauryl Dimethylamine-N-Oxide
Diseases			Type I diabetes mellitus
GWAS		Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 27182965 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 21841780 22922229) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte counts ( 27863252) Mean corpuscular volume ( 27863252) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 21829393 25751624 19430480 18840781 18978792) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 27863252)
Interacting Genes		15 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA	8 interacting genes: BATF3 DDIT3 MAFF MAFG MAFK NFE2L1 NFE2L3 PATZ1
Entrez ID		4779	60468
HPRD ID		01223	12012
Ensembl ID		ENSG00000082641	ENSG00000112182
Uniprot IDs		J9JIE5 Q14494 Q8NF22	Q9BYV9
PDB IDs			3OHU 3OHV
Enriched GO Terms of Interacting Partners?
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