BACH2 and PATZ1

Number of citations of the paper that reports this interaction (PubMedID 10669750)
42

Data Source:
HPRD (in vivo, two hybrid)

		BACH2	PATZ1
Description		BTB domain and CNC homolog 2	POZ/BTB and AT hook containing zinc finger 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Spermatogenesis Male Gonad Development T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 27182965 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 21841780 22922229) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte counts ( 27863252) Mean corpuscular volume ( 27863252) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 21829393 25751624 19430480 18840781 18978792) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 27863252)	Height ( 31562340) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		8 interacting genes: BATF3 DDIT3 MAFF MAFG MAFK NFE2L1 NFE2L3 PATZ1	7 interacting genes: BACH1 BACH2 CLK1 MITF PRKAR1A RBPMS RNF4
Entrez ID		60468	23598
HPRD ID		12012	05522
Ensembl ID		ENSG00000112182	ENSG00000100105
Uniprot IDs		Q9BYV9	A0A024R1F8 A0A024R1H7 A0A024R1M5 Q9HBE1
PDB IDs		3OHU 3OHV	2EPP 2EPQ 2EPR 2EPS 2YT9
Enriched GO Terms of Interacting Partners?
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