HNRNPM and AKAP9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HNRNPM	AKAP9
Description		heterogeneous nuclear ribonucleoprotein M	A-kinase anchoring protein 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Membrane Nuclear Matrix Paraspeckles Collagen-containing Extracellular Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Ribonucleoprotein Complex	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Regulation Of MRNA Stability Involved In Response To Oxidative Stress	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Coronary artery disease ( 29212778)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		25 interacting genes: AKAP9 APC CDC5L CEACAM5 ECPAS GMCL2 HNRNPF JUN LMO2 LMO3 LYST PLRG1 PRRC2A RBM4 RBM4B SMARCB1 STAT3 TCERG1 TEKT4 U2AF1 UBC UBE2I WDR77 YWHAG ZNF207	67 interacting genes: ASB4 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 DVL2 FMR1 FNBP1 FXR2 GATAD1 GPC4 GRIN1 GTSE1 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 SAMD3 SF3B2 SGCE SLAIN1 SSX2 SUV39H2 TACC3 TDP2 THAP1 TNIK TRIP10 TSG101 TSNAX TUBGCP3 USHBP1 USO1 WAC YWHAE
Entrez ID		4670	10142
HPRD ID		01188	04921
Ensembl ID		ENSG00000099783	ENSG00000127914
Uniprot IDs		P52272 Q59ES8	Q5GIA7 Q6PJH3 Q99996
PDB IDs		2DGV 2DH9 2DO0 2OT8
Enriched GO Terms of Interacting Partners?
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