AKAP9 and TSG101

Number of citations of the paper that reports this interaction (PubMedID 18643869)
13

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		AKAP9	TSG101
Description		A-kinase anchoring protein 9	tumor susceptibility 101
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	ESCRT I Complex Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Microtubule Organizing Center Cytosol Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane Host Cell Extracellular Exosome Flemming Body
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity	DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization	Regulation Of Cell Growth Protein Monoubiquitination Extracellular Transport Cell Cycle Arrest Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Intracellular Transport Of Virus Autophagosome Maturation Regulation Of Viral Release From Host Cell Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		67 interacting genes: ASB4 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 DVL2 FMR1 FNBP1 FXR2 GATAD1 GPC4 GRIN1 GTSE1 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 SAMD3 SF3B2 SGCE SLAIN1 SSX2 SUV39H2 TACC3 TDP2 THAP1 TNIK TRIP10 TSG101 TSNAX TUBGCP3 USHBP1 USO1 WAC YWHAE	88 interacting genes: AATF ADRB2 AKAP9 AR ARRDC1 BCAS3 BCR BIRC2 CCND3 CDKN1A CDKN2D CDS2 CEP55 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 NR3C1 PDCD6IP PDLIM7 PIAS1 PPFIBP2 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCGB3A1 SCNN1A SH3GLB2 SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 THRB THRSP TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBC USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		10142	7251
HPRD ID		04921	03229
Ensembl ID		ENSG00000127914	ENSG00000074319
Uniprot IDs		Q5GIA7 Q6PJH3 Q99996	Q99816
PDB IDs			1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG
Enriched GO Terms of Interacting Partners?
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