MLLT1 and AFF1

Number of citations of the paper that reports this interaction (PubMedID 25921070)
54

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		MLLT1	AFF1
Description		MLLT1 super elongation complex subunit	AF4/FMR2 family member 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex	Nucleus Transcription Elongation Factor Complex ELL-EAF Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity	Regulation Of Transcription, DNA-templated Regulation Of Gene Expression
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)	Alzheimer's disease (cognitive decline) ( 23535033) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010 27863252) Hemoglobin ( 29403010) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Red blood cell count ( 27863252) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 30275531 25961943 20686565) White blood cell count (basophil) ( 29403010 27863252)
Interacting Genes		11 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 H1-5 H3-4 MLLT10 PAF1 WDR5	9 interacting genes: H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9 TBCA
Entrez ID		4298	4299
HPRD ID		15933	08871
Ensembl ID		ENSG00000130382	ENSG00000172493
Uniprot IDs		Q03111	B4DJU9 P51825 Q14C88
PDB IDs		5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O	2LM0
Enriched GO Terms of Interacting Partners?
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