AFF1 and NT5E

Number of citations of the paper that reports this interaction (PubMedID 19956800)
85

Data Source:
BioGRID (two hybrid)

		AFF1	NT5E
Description		AF4/FMR2 family member 1	5'-nucleotidase ecto
Image
GO Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex ELL-EAF Complex	Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Gene Expression	Purine Nucleotide Catabolic Process AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Dephosphorylation NAD Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response
Pathways			Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs			Pentoxifylline
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Calcification of joints and arteries
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010 27863252) Hemoglobin ( 29403010) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Red blood cell count ( 27863252) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 30275531 25961943 20686565) White blood cell count (basophil) ( 29403010 27863252)	Blood metabolite levels ( 24816252) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolic traits ( 21886157)
Interacting Genes		9 interacting genes: H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9 TBCA	5 interacting genes: ACTB AFF1 ATP6AP1 FN1 LAMA1
Entrez ID		4299	4907
HPRD ID		08871	00552
Ensembl ID		ENSG00000172493	ENSG00000135318
Uniprot IDs		B4DJU9 P51825 Q14C88	P21589 Q6NZX3
PDB IDs		2LM0	4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW
Enriched GO Terms of Interacting Partners?
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