MLLT1 and MLLT10

Number of citations of the paper that reports this interaction (PubMedID 15856011)
39

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		MLLT1	MLLT10
Description		MLLT1 super elongation complex subunit	MLLT10 histone lysine methyltransferase DOT1L cofactor
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex	Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)	Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Ovarian cancer ( 23535730) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)
Interacting Genes		11 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 H1-5 H3-4 MLLT10 PAF1 WDR5	7 interacting genes: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4
Entrez ID		4298	8028
HPRD ID		15933	03874
Ensembl ID		ENSG00000130382	ENSG00000078403
Uniprot IDs		Q03111	P55197 Q59EQ6 Q6N002
PDB IDs		5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O	5DAG 5DAH 6CKN 6CKO 6JN2
Enriched GO Terms of Interacting Partners?
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