ATXN3 and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		ATXN3	TRIM63
Description		ataxin 3	tripartite motif containing 63
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding Histone Deacetylase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Histone H3 Deacetylation Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666)
Interacting Genes		50 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MAP3K1 MKNK1 NCOR1 NEDD8 PICK1 PJA1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP	93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		4287	84676
HPRD ID		06131	05843
Ensembl ID		ENSG00000066427	ENSG00000158022
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	Q969Q1
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
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