TRIM63 and PKM

Number of citations of the paper that reports this interaction (PubMedID 18468620)
27

Data Source:
HPRD (two hybrid)

		TRIM63	PKM
Description		tripartite motif containing 63	pyruvate kinase M1/2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cilium Vesicle Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Pyruvate Kinase Complex Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding	Magnesium Ion Binding RNA Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Identical Protein Binding ADP Binding Cadherin Binding Thyroid Hormone Binding
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	Response To Hypoxia Liver Development Glycolytic Process ATP Biosynthetic Process Response To Nutrient Response To Gravity Programmed Cell Death Response To Muscle Inactivity Animal Organ Regeneration Cellular Response To Insulin Stimulus Pyruvate Biosynthetic Process Neutrophil Degranulation Skeletal Muscle Tissue Regeneration Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs			Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Copper Artenimol
Diseases
GWAS
Interacting Genes		93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	46 interacting genes: ANXA7 APP ARAF AURKB CDC25A CDK4 CDKN1A CTNNB1 EGLN3 EPM2A EXOSC5 GRB7 HERC1 HIF1A KPNA1 LMO7 LNX1 MAPK1 MDM2 MYL2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 SUMO1 TERF1 TINF2 TK1 TRIM35 TRIM63 UCHL5 YWHAQ
Entrez ID		84676	5315
HPRD ID		05843	01529
Ensembl ID		ENSG00000158022	ENSG00000067225
Uniprot IDs		Q969Q1	A0A024R5Z9 B4DNK4 P14618 V9HWB8
PDB IDs		2D8U 3DDT 4M3L	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6NU1 6NU5 6NUB
Enriched GO Terms of Interacting Partners?
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