TRIM63 and ESPL1

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		TRIM63	ESPL1
Description		tripartite motif containing 63	extra spindle pole bodies like 1, separase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Cell Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Separation of Sister Chromatids
Drugs
Diseases
GWAS			Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)
Interacting Genes		93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28
Entrez ID		84676	9700
HPRD ID		05843	06825
Ensembl ID		ENSG00000158022	ENSG00000135476
Uniprot IDs		Q969Q1	Q14674
PDB IDs		2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
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