MEF2D and HDAC5

Number of citations of the paper that reports this interaction (PubMedID 10737771)
177

Data Source:
HPRD (in vivo, in vitro)

		MEF2D	HDAC5
Description		myocyte enhancer factor 2D	histone deacetylase 5
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Repressing Transcription Factor Binding
	Biological Process	Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Apoptotic Process Multicellular Organism Development Nervous System Development Adult Heart Development Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Smooth Muscle Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis NGF-stimulated transcription NGF-stimulated transcription	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Belinostat Panobinostat
Diseases
GWAS		Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Platelet count ( 27863252) Plateletcrit ( 27863252)	Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		23 interacting genes: APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ	60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16
Entrez ID		4209	10014
HPRD ID		02810	09246
Ensembl ID		ENSG00000116604	ENSG00000108840
Uniprot IDs		Q14814	Q9UQL6
PDB IDs			5UWI
Enriched GO Terms of Interacting Partners?
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